Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066901 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 | |
| SCHEMBL28249003 | 0.88 | MTNR1A (0.42) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 | |
| SCHEMBL9240061 | 0.87 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL11146721 | 0.85 | MTNR1A (0.47) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL28599443 | 0.84 | MTNR1A (0.49) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL28138447 | 0.84 | MTNR1A (0.49) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 | |
| SCHEMBL5370015 | 0.84 | MTNR1A (0.56) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL8440245 | 0.83 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 | |
| SCHEMBL28007657 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BKDM4EOPRL1OPRM1 | |
| SCHEMBL21847558 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BALDH1A1KDM4EOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113121562-B | Polycyclic compounds as inhibitors of bruton's tyrosine kinase | 詹森药业有限公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-113105475-B | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-113121562-A | Polycyclic compounds as inhibitors of bruton's tyrosine kinase | 詹森药业有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-113105475-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108884106-A | POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE | 詹森药业有限公司 | 2018-11-23 | — | — | CN | disclosed |
| EP-1819684-B1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INT BV (NL) | 2013-08-07 | — | — | EP | disclosed |
| US-8236805-B2 | Substituted piperazines as CB1 antagonists | INTERVET INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-7700597-B2 | Substituted piperazines as CB1 antagonists | SCHERING CORPORATION (US) | 2010-04-20 | — | — | US | disclosed |
| US-7700597-B2 | Substituted piperazines as CB1 antagonists | SCHERING CORPORATION (US) | 2010-04-20 | — | — | US | disclosed |
| EP-0256456-B1 | PIGMENT COMPOSITION | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1993-03-10 | — | — | EP | disclosed |
| EP-0256454-B1 | PIGMENT COMPOSITION | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5019588-A | Nonhabit-forming analgeiscs | WARNER-LAMBERT COMPANY (US) | 1991-05-28 | — | — | US | disclosed |
| EP-0380063-A1 | 1,2-cyclohexylaminoaryl amides useful as analgesic agents | WARNER-LAMBERT COMPANY (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4906655-A | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |
| US-4767465-A | POLYESTER DISPERSANT | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4762568-A | PHOSPHORIC ESTER OF A POLYESTER AS DISPERSANT | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 1988-08-09 | — | — | US | disclosed |
| EP-0256454-A2 | Pigment composition | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |
| EP-0256456-A2 | Pigment composition | DAINICHISEIKA COLOR & CHEMICALS MFG. CO. LTD. (JP) | 1988-02-24 | — | — | EP | disclosed |
| US-4226790-A | ALKANOATE SALTS, WITH PEROXY CARBOXYLIC ACID, MANGANESE SALT | THE UPJOHN COMPANY (US) | 1980-10-07 | — | — | US | disclosed |