Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 2/20 | 0.31 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL28311968 | 0.83 | THRB (0.48) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL9321905 | 0.83 | THRB (0.55) | THRBTSHRPOLBAPEX1HTT | |
| Acetic Acid SCHEMBL11303299 | 0.82 | TSHR (0.47) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL4650020 | 0.82 | TSHR (0.50) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL28050152 | 0.82 | THRB (0.47) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL13950019 | 0.81 | THRB (0.53) | THRBTSHRPOLBAPEX1HTT | |
| Hydrochloric Acid SCHEMBL11790765 | 0.80 | TSHR (0.49) | THRBTSHRPOLBAPEX1HTT | |
| Glycine SCHEMBL28290813 | 0.78 | THRB (0.50) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL19951569 | 0.78 | THRB (0.43) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL11222545 | 0.76 | THRB (0.48) | THRBTSHRPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102677-B | Surface modification of metals and method for being modified to metal surface | 住友橡胶工业株式会社 | 2018-09-28 | — | — | CN | disclosed |