SCHEMBL28249586

SCHEMBL28249586

O=C(O)c1cc(OC(=O)c2cccnc2)cc(C(=O)O)c1

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.61
ATM Q13315 1/20 0.61
ALDH1A1 P00352 8/20 0.61
CYP1A2 P05177 4/20 0.61
CYP2C19 P33261 3/20 0.61
CYP2C9 P11712 3/20 0.61
TSHR P16473 2/20 0.61
APP P05067 1/20 0.61
GAA P10253 1/20 0.61
HCAR3 P49019 1/20 0.61
HCAR2 Q8TDS4 1/20 0.61
MAPT P10636 3/20 0.58
KDM4E B2RXH2 2/20 0.58
LMNA P02545 3/20 0.58
CYP3A4 P08684 2/20 0.58
THRB P10828 1/20 0.57
USP2 O75604 1/20 0.54
ALOX15 P16050 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23488239 0.86 KMT2A (0.72) KMT2AATMALDH1A1CYP1A2CYP2C19
SCHEMBL502583 0.83 ALDH1A1 (0.78) KMT2AATMALDH1A1CYP1A2CYP2C19
SCHEMBL21243070 0.83 KMT2A (0.84) KMT2AATMALDH1A1CYP1A2CYP2C19
SCHEMBL22014075 0.82 ALDH1A1 (0.73) KMT2AATMALDH1A1CYP1A2CYP2C19
SCHEMBL28423662 0.81 KMT2A (0.59) KMT2AALDH1A1TSHRMAPTLMNA
SCHEMBL28777485 0.81 KMT2A (0.75) KMT2AATMALDH1A1CYP1A2CYP2C19
SCHEMBL28270189 0.80 HSD17B10 (0.67) CYP1A2CYP2C19CYP2C9GAAMAPT
SCHEMBL11264314 0.80 AKR1C3 (0.56) KMT2ACYP1A2CYP2C9GAAMAPT
SCHEMBL22014585 0.78 KMT2A (0.78) KMT2AATMALDH1A1CYP1A2CYP2C19
SCHEMBL11202828 0.78 AKR1C3 (0.55) KMT2AGAAMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108654564-A A kind of preparation method and applications of coordination polymer porous material 聊城大学 2018-10-16 CN claimed
CN-108654564-A A kind of preparation method and applications of coordination polymer porous material 聊城大学 2018-10-16 CN disclosed
CN-108654564-A A kind of preparation method and applications of coordination polymer porous material 聊城大学 2018-10-16 CN disclosed