Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27602582 | 0.93 | IDO1 (0.60) | IDO1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL456128 | 0.84 | MAPT (0.59) | IDO1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL16193023 | 0.83 | MAPT (0.54) | IDO1MAPTKDM4EGAAALDH1A1 | |
| Alcohol SCHEMBL28251608 | 0.82 | IDO1 (0.85) | IDO1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL17637653 | 0.82 | RAB9A (0.57) | MAPTKDM4EGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL23022690 | 0.82 | IDO1 (0.60) | IDO1MAPTKDM4EGAASMN1; SMN2 | |
| Alcohol SCHEMBL28158907 | 0.80 | ALDH1A1 (0.59) | IDO1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL455344 | 0.79 | IDO1 (0.78) | IDO1MAPTKDM4EGAASMN1; SMN2 | |
| Alcohol SCHEMBL28251587 | 0.78 | MAPT (0.64) | IDO1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL28109108 | 0.77 | ALDH1A1 (0.65) | MAPTKDM4EGAAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106699779-B | Rufloxacin aldehyde contracting 4- arylamino thiourea derivatives and its preparation method and application | 郑州工业应用技术学院 | 2018-11-09 | — | — | CN | disclosed |