Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980224 | 0.79 | PRKCG (0.47) | DRD2DRD4NOTUMPRKCGPRKCA | |
| SCHEMBL13523574 | 0.79 | PRKCG (0.47) | DRD2DRD4NOTUMPRKCGPRKCA | |
| SCHEMBL4737682 | 0.78 | DRD2 (0.40) | DRD2DRD4NOTUMPRKCGPRKCA | |
| SCHEMBL2705982 | 0.78 | DRD2 (0.40) | DRD2DRD4NOTUMPRKCGPRKCA | |
| SCHEMBL18899034 | 0.75 | DRD2 (0.38) | DRD2DRD4NOTUMPRKCGPRKCA | |
| SCHEMBL28888363 | 0.75 | NOTUM (0.53) | NOTUMHTR2AHTR2CHTR2B | |
| SCHEMBL13210097 | 0.73 | NOTUM (0.64) | DRD2DRD4NOTUMACEBRS3 | |
| SCHEMBL28217735 | 0.72 | NOTUM (0.42) | NOTUMHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL27013835 | 0.70 | DRD2 (0.36) | DRD2DRD4NOTUMPRKCGPRKCA | |
| SCHEMBL28162936 | 0.69 | PRKCD (0.55) | DRD2DRD4PRKCGPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189508-B | Naphthenic base nitrile Pyrazolopyridine ketone as JANUS kinase inhibitor | 默沙东公司 | 2018-11-23 | — | — | CN | disclosed |