Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348654 | 0.91 | HPGD (0.43) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1348854 | 0.89 | ALDH1A1 (0.41) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1348175 | 0.86 | MAPK1 (0.39) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1348667 | 0.82 | HPGD (0.46) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1349043 | 0.78 | HPGD (0.43) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1347622 | 0.77 | HPGD (0.41) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1348729 | 0.76 | LMNA (0.38) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2827448 | 0.76 | LMNA (0.40) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2826923 | 0.75 | POLB (0.40) | HPGDALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL1348596 | 0.75 | POLB (0.38) | HPGDALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863818-B1 | ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-03-10 | — | — | EP | disclosed |