Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 7/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.64 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28257373 | 0.87 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2SMN1; SMN2 | |
| SCHEMBL29793677 | 0.87 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2SMN1; SMN2 | |
| SCHEMBL28257359 | 0.82 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2SMN1; SMN2 | |
| SCHEMBL28402258 | 0.81 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2LMNA | |
| SCHEMBL28257405 | 0.80 | KCNB1 (0.70) | KCNB1KCNH2KCNA5KCNB2LMNA | |
| SCHEMBL28406389 | 0.79 | KCNB1 (0.72) | KCNB1KCNH2KCNA5KCNB2SMN1; SMN2 | |
| SCHEMBL29793630 | 0.79 | GAA (0.52) | KCNB1KCNH2SMN1; SMN2LMNAHTT | |
| SCHEMBL28257360 | 0.79 | GAA (0.52) | KCNB1KCNH2SMN1; SMN2LMNAHTT | |
| SCHEMBL28257391 | 0.78 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2NPSR1 | |
| SCHEMBL28411195 | 0.76 | KCNB1 (0.76) | KCNB1KCNH2KCNA5KCNB2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |
| CN-108929263-A | Aryl amide Kv2.1 inhibitor and preparation method thereof, pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | disclosed |