Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.73 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.73 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.61 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.46 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411195 | 0.87 | KCNB1 (0.76) | KCNB1KCNH2KCNA5KCNB2SENP1 | |
| SCHEMBL28257391 | 0.84 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2NPSR1 | |
| SCHEMBL28406389 | 0.84 | KCNB1 (0.72) | KCNB1KCNH2KCNA5KCNB2SENP1 | |
| SCHEMBL28257405 | 0.82 | KCNB1 (0.70) | KCNB1KCNH2KCNA5KCNB2LMNA | |
| SCHEMBL29793677 | 0.82 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2LMNA | |
| SCHEMBL28257373 | 0.82 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2LMNA | |
| SCHEMBL28402250 | 0.81 | KCNB1 (0.83) | KCNB1KCNH2KCNA5KCNB2NR1H4 | |
| SCHEMBL28255802 | 0.81 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2LMNA | |
| SCHEMBL28257359 | 0.78 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2HSD17B10 | |
| SCHEMBL28411165 | 0.78 | KCNB1 (0.64) | KCNB1KCNH2KCNA5KCNB2SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |