Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNB1 | Q14721 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.63 |
| ▸ | KCNB2 | Q92953 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28255802 | 0.82 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2HTT | |
| SCHEMBL28413244 | 0.81 | KCNB1 (0.71) | KCNB1KCNH2KCNA5KCNB2MEN1 | |
| SCHEMBL29793677 | 0.80 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2KMT2A | |
| SCHEMBL28257373 | 0.80 | KCNB1 (0.69) | KCNB1KCNH2KCNA5KCNB2KMT2A | |
| SCHEMBL28257405 | 0.79 | KCNB1 (0.70) | KCNB1KCNH2KCNA5KCNB2MEN1 | |
| SCHEMBL28402258 | 0.78 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2HSD17B10 | |
| SCHEMBL28257391 | 0.78 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2 | |
| SCHEMBL28257421 | 0.77 | CYP1A2 (0.62) | KCNB1KCNH2MEN1KMT2AHSD17B10 | |
| SCHEMBL28406389 | 0.75 | KCNB1 (0.72) | KCNB1KCNH2KCNA5KCNB2HSD17B10 | |
| SCHEMBL29793705 | 0.74 | KCNB1 (1.00) | KCNB1KCNH2KCNA5KCNB2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |
| CN-108929263-A | Aryl amide Kv2.1 inhibitor and preparation method thereof, pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | disclosed |