Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Niacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | APP | P05067 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.72 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.72 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacin SCHEMBL10940705 | 0.92 | ALDH1A1 (0.70) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL31324786 | 0.89 | ALDH1A1 (0.78) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL6712322 | 0.89 | ALDH1A1 (0.84) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL21747599 | 0.88 | ALDH1A1 (0.70) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL28400834 | 0.87 | ALDH1A1 (0.81) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL8168699 | 0.87 | ALDH1A1 (0.81) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL28400835 | 0.87 | ALDH1A1 (0.81) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL27827804 | 0.87 | ALDH1A1 (0.81) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL31228985 | 0.86 | ALDH1A1 (0.78) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL28863183 | 0.86 | ALDH1A1 (0.78) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108948212-A | Long-actingization oxyntomodulin (OXM) hybrid peptide and the preparation method and application thereof | 中国药科大学 | 2018-12-07 | — | — | CN | claimed |
| CN-107522669-B | 1 antagonist of transient receptor potential vanillic acid hypotype and its preparation method and application | 重庆美莱德生物医药有限公司 | 2019-12-03 | — | — | CN | disclosed |
| CN-107522668-B | TRPV1 antagonist and its preparation method and application | 重庆医科大学 | 2019-12-03 | — | — | CN | disclosed |
| CN-106804107-B | New benzodiazepine * analog derivative and application thereof | 江苏恩华络康药物研发有限公司 | 2019-03-12 | — | — | CN | disclosed |