Niacin

Niacin

SCHEMBL31228985

CCN.O=C(O)c1cccnc1

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.78
GAA P10253 2/20 0.78
APP P05067 1/20 0.78
HCAR3 P49019 1/20 0.78
HCAR2 Q8TDS4 1/20 0.78
F7 P08709 1/20 0.58
F3 P13726 1/20 0.58
SARM1 Q6SZW1 1/20 0.58
SIRT2 Q8IXJ6 1/20 0.58
SIRT6 Q8N6T7 1/20 0.58
SIRT1 Q96EB6 1/20 0.58
SIRT3 Q9NTG7 1/20 0.58
SIRT5 Q9NXA8 1/20 0.58
SIRT4 Q9Y6E7 1/20 0.58
PLOD2 O00469 1/20 0.56
HTT P42858 1/20 0.54
KMO O15229 1/20 0.53
MKNK1 Q9BUB5 1/20 0.51
MKNK2 Q9HBH9 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niacin SCHEMBL8168699 0.91 ALDH1A1 (0.81) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL28062347 0.90 ALDH1A1 (0.88) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL27753119 0.89 ALDH1A1 (0.78) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL21749562 0.89 ALDH1A1 (0.78) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL8159845 0.89 ALDH1A1 (0.78) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL28863183 0.89 ALDH1A1 (0.78) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL11441069 0.88 ALDH1A1 (0.91) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL20482455 0.88 ALDH1A1 (0.91) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL1640446 0.88 ALDH1A1 (0.91) ALDH1A1GAAAPPHCAR3HCAR2
Niacin SCHEMBL29396199 0.88 ALDH1A1 (1.00) ALDH1A1GAAAPPHCAR3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118730686-A Separation and structure identification method of unknown impurities in imazethapyr original drug 湖北泰盛化工有限公司 2024-10-01 CN claimed
CN-118730686-A Separation and structure identification method of unknown impurities in imazethapyr original drug 湖北泰盛化工有限公司 2024-10-01 CN disclosed