Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227656 | 0.81 | PHGDH (0.71) | PHGDHALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL6183139 | 0.77 | GAA (0.60) | ALDH1A1NAPRTKDM4EPOLBMAPT | |
| SCHEMBL28311845 | 0.75 | GAA (0.57) | ALDH1A1KDM4EPOLBMAPTGAA | |
| SCHEMBL9954499 | 0.73 | HDAC8 (0.51) | ALDH1A1NAPRTKDM4ENAMPTSMN1; SMN2 | |
| SCHEMBL27486134 | 0.72 | PHGDH (0.71) | PHGDHALDH1A1POLBMAPTTSHR | |
| SCHEMBL17131916 | 0.72 | PHGDH (1.00) | PHGDHALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL1864065 | 0.71 | PHGDH (0.54) | PHGDHALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL29634403 | 0.71 | SMN1; SMN2 (0.62) | ALDH1A1POLBMAPTGAAKMT2A | |
| SCHEMBL1020349 | 0.70 | TDP1 (0.62) | PHGDHALDH1A1MAPTTSHR | |
| SCHEMBL2478525 | 0.70 | SMN1; SMN2 (0.45) | ALDH1A1MAPTGAAPIK3CAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884046-A | chemical compounds as inhibitors of kinase activity | 葛兰素史克知识产权开发有限公司 | 2018-11-23 | — | — | CN | claimed |
| CN-108884046-A | chemical compounds as inhibitors of kinase activity | 葛兰素史克知识产权开发有限公司 | 2018-11-23 | — | — | CN | disclosed |