Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.53 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.53 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14096482 | 0.87 | HTT (0.57) | SMN1; SMN2TP53GAAALDH1A1POLB | |
| SCHEMBL29634427 | 0.86 | HTT (0.63) | SMN1; SMN2TP53GAAALDH1A1MEN1 | |
| SCHEMBL29634479 | 0.85 | HTT (0.66) | SMN1; SMN2TP53ALDH1A1HDAC1HDAC6 | |
| SCHEMBL4538968 | 0.82 | ALDH1A1 (0.56) | SMN1; SMN2TP53GAAALDH1A1MEN1 | |
| SCHEMBL8637476 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53GAAALDH1A1PLOD2 | |
| Hydrochloric Acid SCHEMBL18281395 | 0.81 | ALDH1A1 (0.54) | SMN1; SMN2TP53GAAALDH1A1MEN1 | |
| SCHEMBL3955220 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2GAAALDH1A1CYP2D6KMT2A | |
| SCHEMBL6826302 | 0.80 | RAB9A (0.62) | SMN1; SMN2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL22982793 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53GAAALDH1A1HDAC1 | |
| Hydrochloric Acid SCHEMBL30589354 | 0.79 | HDAC1 (0.49) | SMN1; SMN2GAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3388433-B1 | PHTHALAZINE DERIVATIVES, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI SIMR BIOTECH CO LTD (CN) | 2023-08-30 | — | — | EP | claimed |
| CN-107344936-B | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2022-06-03 | — | — | CN | disclosed |