Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825229 | 0.88 | CACNA2D1 (0.50) | POLBCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL12378355 | 0.87 | ADRB1 (0.56) | — | |
| SCHEMBL12378461 | 0.84 | GFER (0.54) | POLB | |
| SCHEMBL2293188 | 0.84 | KMT2A (0.55) | POLB | |
| SCHEMBL12378428 | 0.84 | GFER (0.54) | POLB | |
| SCHEMBL2293971 | 0.84 | GFER (0.54) | POLB | |
| SCHEMBL2294698 | 0.83 | CACNA2D1 (0.71) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL12378457 | 0.83 | ADRB1 (0.54) | — | |
| SCHEMBL12378468 | 0.83 | ME2 (0.55) | — | |
| SCHEMBL2288557 | 0.83 | ME2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155736-A1 | NOVEL CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK Holdings Co., Ltd. (KR) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008140198-A1 | NOVEL CARBAMOYLOXY ARYLALKANOYL ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND | SK HOLDINGS CO., LTD. (KR) | 2008-11-20 | — | — | WO | disclosed |