Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | BCL9 | O00512 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | ACACA | Q13085 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12006548 | 0.87 | ALDH1A1 (0.71) | ALDH1A1MAPTMAPK1KDM4ELMNA | |
| SCHEMBL3455666 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MAPTMAPK1KDM4ELMNA | |
| SCHEMBL4961935 | 0.79 | NOTUM (0.81) | ALDH1A1MAPTMAPK1KDM4EHSD17B10 | |
| SCHEMBL613112 | 0.79 | NOTUM (0.81) | ALDH1A1MAPTMAPK1KDM4EHSD17B10 | |
| SCHEMBL14504051 | 0.79 | ALDH1A1 (0.61) | ALDH1A1MAPTMAPK1KDM4ELMNA | |
| SCHEMBL3455456 | 0.78 | ALDH1A1 (1.00) | ALDH1A1MAPTMAPK1KDM4ELMNA | |
| SCHEMBL31175186 | 0.78 | ALDH1A1 (0.70) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL12777820 | 0.78 | KDM4E (0.60) | ALDH1A1MAPTKDM4ELMNAHPGD | |
| SCHEMBL12311912 | 0.78 | ALDH1A1 (0.59) | ALDH1A1MAPTMAPK1KDM4ELMNA | |
| SCHEMBL2446475 | 0.77 | KMT2A (0.62) | ALDH1A1MAPTMAPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715617-A | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2019-05-03 | — | — | CN | claimed |
| CN-109715617-A | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109641895-A | Indole compounds substituted with [1, 2, 4] triazolo [1, 5-a ] pyridyl | 百时美施贵宝公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-104876955-B | Arginase inhibitor and its treatment use | 马尔斯公司 | 2018-11-23 | — | — | CN | disclosed |