Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830083 | 0.96 | GRM5 (0.54) | GRM5RAB9AJAK2JAK3MEN1 | |
| SCHEMBL2824785 | 0.87 | GRM5 (0.70) | GRM5RAB9AJAK2JAK3MEN1 | |
| SCHEMBL2829770 | 0.83 | GRM5 (0.57) | GRM5RAB9AJAK2JAK3MEN1 | |
| SCHEMBL2829704 | 0.83 | GRM5 (0.57) | GRM5RAB9AJAK2JAK3MEN1 | |
| SCHEMBL2826351 | 0.82 | GRM5 (0.55) | GRM5 | |
| SCHEMBL2827399 | 0.82 | GRM5 (0.55) | GRM5RAB9AJAK2JAK3MEN1 | |
| SCHEMBL2825843 | 0.81 | GRM5 (0.58) | GRM5RAB9AMEN1NPC1GBA1 | |
| SCHEMBL2827039 | 0.80 | GRM5 (0.56) | GRM5RAB9AJAK2JAK3MEN1 | |
| SCHEMBL2826008 | 0.78 | GRM5 (0.57) | GRM5JAK2JAK3MEN1KMT2A | |
| SCHEMBL2826273 | 0.77 | GRM5 (0.56) | GRM5RAB9AJAK2JAK3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |