Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824785 | 0.91 | GRM5 (0.70) | GRM5JAK2JAK3MEN1KMT2A | |
| SCHEMBL2829877 | 0.90 | GRM5 (0.45) | GRM5ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2826273 | 0.89 | GRM5 (0.56) | GRM5JAK2JAK3LCKPIK3CA | |
| SCHEMBL2830049 | 0.87 | GRM5 (0.60) | GRM5JAK2JAK3PIK3CAPIK3CG | |
| SCHEMBL2826781 | 0.86 | GRM5 (0.52) | GRM5CDK5CDK5R1MAPTTP53 | |
| SCHEMBL2826585 | 0.86 | GRM5 (0.52) | GRM5JAK2JAK3PIK3CAPIK3CG | |
| SCHEMBL2829034 | 0.85 | GRM5 (0.71) | GRM5JAK2JAK3CDK5CDK5R1 | |
| SCHEMBL2827389 | 0.85 | GRM5 (0.51) | GRM5JAK2JAK3PIK3CAPIK3CG | |
| SCHEMBL2829501 | 0.84 | GRM5 (0.45) | GRM5JAK2JAK3LCKALDH1A1 | |
| SCHEMBL2827009 | 0.84 | GRM5 (0.53) | GRM5JAK2JAK3MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |