Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829501 | 0.89 | GRM5 (0.45) | GRM5NAMPTRAB9AMEN1KMT2A | |
| SCHEMBL2830797 | 0.88 | RAB9A (0.51) | GRM5RAB9ANPC1MEN1GBA1 | |
| SCHEMBL2828918 | 0.88 | GRM5 (0.44) | GRM5NAMPTNPC1SMN1; SMN2 | |
| SCHEMBL2832364 | 0.87 | GRM5 (0.55) | GRM5NAMPTRAB9ANPC1 | |
| SCHEMBL2829262 | 0.86 | GRM5 (0.44) | GRM5NAMPTSMN1; SMN2 | |
| SCHEMBL2824785 | 0.86 | GRM5 (0.70) | GRM5RAB9ANPC1MEN1GBA1 | |
| SCHEMBL2828432 | 0.85 | GRM5 (0.42) | GRM5NAMPT | |
| SCHEMBL2826737 | 0.84 | RAB9A (0.56) | GRM5RAB9ANPC1MEN1GBA1 | |
| SCHEMBL2824997 | 0.84 | GRM5 (0.48) | GRM5NAMPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2833180 | 0.83 | RAB9A (0.54) | GRM5RAB9ANPC1MEN1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |