Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822901 | 0.88 | PTGS1 (0.45) | PTGS1PTGS2POLBSMYD3HPGD | |
| SCHEMBL8443948 | 0.87 | PTGS1 (0.40) | PTGS1PTGS2POLBSMYD3HSD17B10 | |
| SCHEMBL8441523 | 0.81 | PTGS1 (0.40) | PTGS1PTGS2POLBSMYD3HPGD | |
| SCHEMBL2824525 | 0.81 | KMT2A (0.42) | PTGS1PTGS2POLBSMYD3ALDH1A1 | |
| SCHEMBL15957211 | 0.81 | PTGS1 (0.42) | PTGS1PTGS2POLBSMYD3KMT2A | |
| SCHEMBL8443954 | 0.79 | MAPK14 (0.53) | PTGS1PTGS2CA1CA2CA9 | |
| SCHEMBL2825617 | 0.79 | TUBB4A (0.50) | NPSR1TSHRSMYD3ALDH1A1HSD17B10 | |
| SCHEMBL13291129 | 0.78 | NPSR1 (0.45) | NPSR1TSHRSMYD3CA9ALDH1A1 | |
| SCHEMBL15539288 | 0.78 | MLYCD (0.40) | ALDH1A1HPGDKMT2AMEN1RAB9A | |
| SCHEMBL1232115 | 0.76 | SMYD3 (0.50) | SMYD3HSD17B10HPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |