Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23115927 | 0.90 | AURKA (0.39) | KDM4EMAPK1AURKARPS6KB1ALDH1A1 | |
| SCHEMBL20419549 | 0.87 | AURKA (0.40) | KDM4EL3MBTL1MAPK1MARS1AURKA | |
| SCHEMBL3646146 | 0.84 | MARS1 (0.46) | KDM4EL3MBTL1MARS1AURKARPS6KB1 | |
| SCHEMBL17962537 | 0.81 | MARS1 (0.44) | KDM4EL3MBTL1MARS1AURKARPS6KB1 | |
| SCHEMBL20488433 | 0.81 | SMN1; SMN2 (0.53) | MARS1POLBP2RY14 | |
| SCHEMBL29624900 | 0.81 | BRD4 (0.45) | KDM4EL3MBTL1MARS1AURKARPS6KB1 | |
| SCHEMBL5108674 | 0.80 | KDM4E (0.38) | KDM4EL3MBTL1ALDH1A1GAAPOLB | |
| SCHEMBL106285 | 0.80 | MAPT (0.52) | KDM4EALDH1A1GAAPOLB | |
| SCHEMBL3817969 | 0.79 | CA12 (0.37) | KDM4EALDH1A1GAAPOLBHTT | |
| SCHEMBL31094892 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1GAAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071468-B | Heterocyclic compound and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-109071468-A | Heterocyclic compound and preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2018-12-21 | — | — | CN | disclosed |