Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28498357 | 0.86 | EGFR (0.66) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL28489977 | 0.83 | EGFR (0.60) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL28498241 | 0.82 | FGFR3 (0.69) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL374876 | 0.82 | EGFR (0.71) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL374616 | 0.81 | FGFR3 (0.82) | EGFRFGFR1ERBB3FGFR3 | |
| SCHEMBL28489979 | 0.77 | EGFR (0.62) | EGFRFGFR1ERBB3MEN1KMT2A | |
| SCHEMBL374803 | 0.76 | FGFR3 (0.69) | EGFRFGFR1ERBB3FGFR3 | |
| SCHEMBL28260312 | 0.75 | EGFR (1.00) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL374106 | 0.74 | EGFR (0.67) | EGFRFGFR1FGFR3 | |
| SCHEMBL582431 | 0.74 | FGFR3 (0.71) | EGFRFGFR1ERBB3FGFR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053592-B | 1- (2, 5-dimethoxyphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-04 | — | — | CN | disclosed |