Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | RECQL | P46063 | 4/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | BLM | P54132 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.73 |
| ▸ | CDC25A | P30304 | 2/20 | 0.73 |
| ▸ | CDC25B | P30305 | 2/20 | 0.73 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Plumbagin SCHEMBL28589491 | 0.86 | MAPT (0.87) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL34186 | 0.85 | MAPT (1.00) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL29386213 | 0.85 | MAPT (1.00) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL27811730 | 0.84 | MAPT (0.96) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL28261690 | 0.81 | MAPT (0.73) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL2720467 | 0.80 | MAPT (0.87) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL28261630 | 0.79 | MAPT (0.79) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL3427829 | 0.79 | MAPT (0.84) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL14246176 | 0.79 | MAPT (0.84) | MAPTALDH1A1KDM4ERECQLMAPK1 | |
| Plumbagin SCHEMBL28434705 | 0.78 | MAPT (0.77) | MAPTALDH1A1KDM4ERECQLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020857-B | Plumbagin selenide derivatives, and preparation and application thereof | 浙江中贤生物科技有限公司 | 2020-07-28 | — | — | CN | disclosed |
| CN-109020857-A | Plumbagin selenide analog derivative and its preparation and application | 浙江中贤生物科技有限公司 | 2018-12-18 | — | — | CN | disclosed |