Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.84 |
| ▸ | RECQL | P46063 | 6/20 | 0.84 |
| ▸ | MEN1 | O00255 | 5/20 | 0.84 |
| ▸ | BLM | P54132 | 4/20 | 0.84 |
| ▸ | HPGD | P15428 | 4/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.84 |
| ▸ | CDC25B | P30305 | 4/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.84 |
| ▸ | TP53 | P04637 | 3/20 | 0.84 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.84 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.84 |
| ▸ | CASP1 | P29466 | 2/20 | 0.84 |
| ▸ | CASP7 | P55210 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Plumbagin SCHEMBL14246176 | 0.94 | MAPT (0.84) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL29386213 | 0.92 | MAPT (1.00) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL34186 | 0.92 | MAPT (1.00) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL27811730 | 0.90 | MAPT (0.96) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL2720467 | 0.86 | MAPT (0.87) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL28589491 | 0.86 | MAPT (0.87) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL28261630 | 0.85 | MAPT (0.79) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL28261690 | 0.81 | MAPT (0.73) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL28434705 | 0.81 | MAPT (0.77) | MAPTALDH1A1MAPK1KMT2AKDM4E | |
| Plumbagin SCHEMBL28260352 | 0.80 | MAPT (0.71) | MAPTALDH1A1MAPK1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252569-B1 | ANTIINFECTIVE AND ANTITUMORAL COMPOUNDS ISOLATED FROM TROPICAL LIANAS | JULIUS MAXIMILIANS UNIVERSITÄT WÜRZBURG (DE) | 2016-10-05 | — | — | EP | disclosed |
| US-20140343165-A1 | PLANT PROTECTION AGENT | TECHNISCHE UNIVERSITAET WIEN (AT) | 2014-11-20 | — | — | US | disclosed |
| US-8877718-B2 | Antiinfective and antitumoral compounds isolated from tropical lianas | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2014-11-04 | — | — | US | disclosed |
| US-20120322889-A1 | PLANT PROTECTION AGENT | TECHNISCHE UNIVERSITAET WIEN (AT) | 2012-12-20 | — | — | US | disclosed |
| US-20110059911-A1 | Antiinfective and Antitumoral Compounds Isolated From Tropical Lianas | JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG (DE) | 2011-03-10 | — | — | US | disclosed |
| EP-2252569-A2 | ANTIINFECTIVE AND ANTITUMORAL COMPOUNDS ISOLATED FROM TROPICAL LIANAS | Julius-Maximilians-Universität Würzburg (DE) | 2010-11-24 | — | — | EP | disclosed |
| EP-2093207-A1 | Antiinfective and antitumoral compounds isolated from tropical lianas | Julius-Maximilians-Universität Würzburg (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009098082-A2 | ANTIINFECTIVE AND ANTITUMORAL COMPOUNDS ISOLATED FROM TROPICAL LIANAS | JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322889-A1 | PLANT PROTECTION AGENT | BROX, H1-0, RRS1 | MAPT 3266/4885ALDH1A1 1726/4885MAPK1 1842/4885 |
| US-20110059911-A1 | Antiinfective and Antitumoral Compounds Isolated From Tropical Lianas | NCL, SYNCRIP, MYC | MAPT 4212/4885ALDH1A1 714/4885MAPK1 3499/4885 |
| US-20140343165-A1 | PLANT PROTECTION AGENT | BROX, BOLA2; BOLA2B, RRS1 | MAPT 4151/4885ALDH1A1 4656/4885MAPK1 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.