Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28351993 | 0.87 | LMNA (0.40) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL26605082 | 0.87 | POLB (0.42) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL28355728 | 0.86 | HTR2A (0.43) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL28260550 | 0.85 | BRD4 (0.42) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL28261777 | 0.84 | TSHR (0.42) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL28352016 | 0.82 | KDM4E (0.40) | LMNAALDH1A1KDM4EHPGDIDO1 | |
| SCHEMBL28355808 | 0.81 | SMN1; SMN2 (0.38) | ALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL28356027 | 0.81 | SMN1; SMN2 (0.46) | LMNAHTTALDH1A1KDM4EGAA | |
| SCHEMBL28352234 | 0.81 | BACE1 (0.36) | LMNAALDH1A1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL28260501 | 0.81 | NPSR1 (0.42) | LMNAPOLBHTTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108997183-B | Difluoromethylation reagent and preparation method and application thereof | 深圳大学 | 2020-02-07 | — | — | CN | claimed |
| CN-108997183-B | Difluoromethylation reagent and preparation method and application thereof | 深圳大学 | 2020-02-07 | — | — | CN | disclosed |
| CN-108997183-A | A kind of difluoromethyl reagent and the preparation method and application thereof | 深圳大学 | 2018-12-14 | — | — | CN | disclosed |