SCHEMBL28355808

SCHEMBL28355808

COC(=O)C1(C(F)F)Cc2cc(Cl)ccc2C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.38
SRD5A1 P18405 1/20 0.34
SRD5A2 P31213 1/20 0.34
SDCBP O00560 1/20 0.34
SDC2 P34741 1/20 0.34
BACE1 P56817 3/20 0.34
ALDH1A1 P00352 4/20 0.33
CYP2C19 P33261 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
GAA P10253 1/20 0.33
SLC6A3 Q01959 1/20 0.33
SLC1A3 P43003 1/20 0.33
SLC1A2 P43004 1/20 0.33
SLC1A1 P43005 1/20 0.33
CYP2C9 P11712 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
METAP1 P53582 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28260482 0.81 LMNA (0.41) SMN1; SMN2ALDH1A1GAAKDM4E
SCHEMBL28260511 0.81 SMN1; SMN2 (0.40) SMN1; SMN2SRD5A1SRD5A2ALDH1A1CYP2C19
SCHEMBL28351740 0.81 CXCR5 (0.32) ALDH1A1
SCHEMBL29940608 0.80 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2SDCBPSDC2
SCHEMBL29476750 0.80 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2SDCBPSDC2
SCHEMBL30293721 0.80 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2SDCBPSDC2
SCHEMBL1875543 0.80 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2SDCBPSDC2
SCHEMBL1874449 0.80 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2SDCBPSDC2
SCHEMBL29476749 0.80 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2SDCBPSDC2
SCHEMBL28355990 0.79 CA1 (0.41) ALDH1A1CYP3A4GAAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108997183-B Difluoromethylation reagent and preparation method and application thereof 深圳大学 2020-02-07 CN claimed