Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propranolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.95 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.95 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.95 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.95 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.95 |
| ▸ | HTR2C | P28335 | 4/20 | 0.95 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.95 |
| ▸ | HTR2B | P41595 | 3/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.95 |
| ▸ | HTR2A | P28223 | 3/20 | 0.95 |
| ▸ | HTR6 | P50406 | 3/20 | 0.95 |
| ▸ | HTR1A | P08908 | 3/20 | 0.95 |
| ▸ | LMNA | P02545 | 3/20 | 0.95 |
| ▸ | TSHR | P16473 | 3/20 | 0.95 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.95 |
| ▸ | SCN1A | P35498 | 2/20 | 0.95 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.95 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propranolol SCHEMBL12264958 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Propranolol SCHEMBL1561135 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Levopropranolol SCHEMBL29355940 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Levopropranolol SCHEMBL3956 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Propranolol SCHEMBL3955 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Dexpropranolol SCHEMBL25255 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Dexpropranolol SCHEMBL29577201 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Propranolol SCHEMBL6511347 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Propranolol SCHEMBL10537386 | 0.97 | ADRB2 (1.00) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 | |
| Propranolol SCHEMBL11122479 | 0.96 | ADRB2 (0.92) | ADRB2ADRB1CYP2D6NR2E1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116139274-A | Self-assembled propranolol nano-drug and preparation method thereof | 福建医科大学附属第一医院 | 2023-05-23 | — | — | CN | claimed |
| CN-116139274-A | Self-assembled propranolol nano-drug and preparation method thereof | 福建医科大学附属第一医院 | 2023-05-23 | — | — | CN | disclosed |
| CN-116139274-A | Self-assembled propranolol nano-drug and preparation method thereof | 福建医科大学附属第一医院 | 2023-05-23 | — | — | CN | disclosed |
| CN-113477104-B | Preparation method and application of bionic basswood-based three-dimensional-porous molecularly imprinted nano composite membrane | 江苏大学 | 2023-03-21 | — | — | CN | disclosed |
| CN-113368707-B | Preparation method and application of three-dimensional porous MOFs/poly dopamine-based polycarbonate track etching imprinted membrane | 江苏大学 | 2022-06-21 | — | — | CN | disclosed |
| CN-113477104-A | Preparation method and application of bionic basswood-based three-dimensional-porous molecularly imprinted nano composite membrane | 江苏大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-113368707-A | Preparation method and application of three-dimensional porous MOFs/poly dopamine-based polycarbonate track etching imprinted membrane | 江苏大学 | 2021-09-10 | — | — | CN | disclosed |
| CN-108992397-A | A kind of preparation method of Propranolol sustained release preparation | 刘丽 | 2018-12-14 | — | — | CN | disclosed |