Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 8/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 9/20 | 0.39 |
| ▸ | VEGFA | P15692 | 3/20 | 0.39 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2820385 | 0.99 | TBXA2R (0.42) | TBXA2REPAS1VEGFATRPC6ALDH1A1 | |
| SCHEMBL2821883 | 0.85 | HRH3 (0.39) | TBXA2REPAS1VEGFAALDH1A1KMT2A | |
| SCHEMBL2821885 | 0.85 | HRH3 (0.39) | TBXA2REPAS1VEGFAALDH1A1KMT2A | |
| SCHEMBL2379501 | 0.85 | ALDH1A1 (0.43) | TBXA2REPAS1VEGFATRPC6ALDH1A1 | |
| SCHEMBL2819981 | 0.83 | TRPV4 (0.40) | TBXA2REPAS1VEGFATRPC6ALDH1A1 | |
| SCHEMBL2819983 | 0.83 | TRPV4 (0.40) | TBXA2REPAS1VEGFATRPC6ALDH1A1 | |
| SCHEMBL3125059 | 0.83 | TBXA2R (0.42) | TBXA2REPAS1VEGFAALDH1A1KMT2A | |
| SCHEMBL3123218 | 0.83 | TBXA2R (0.41) | TBXA2REPAS1VEGFA | |
| SCHEMBL13617366 | 0.82 | SPHK2 (0.42) | TBXA2REPAS1VEGFA | |
| SCHEMBL13630672 | 0.82 | TBXA2R (0.38) | TBXA2REPAS1VEGFAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849469-B1 | Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders | AXIKIN PHARMACEUTICALS INC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-1461038-B9 | ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS | ACTIMIS PHARMACEUTICALS INC (US) | 2009-09-23 | — | — | EP | disclosed |
| EP-1849469-A1 | ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS | Actimis Pharmaceuticals, Inc., (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1461038-B1 | ARYLSULFONAMIDE DERIVATIVES FOR USE AS CCR3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISORDERS | ACTIMIS PHARMACEUTICALS INC (US) | 2007-08-01 | — | — | EP | disclosed |