Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828391 | 0.86 | KDM4C (0.40) | ALDH1A1HTTTRPV1KDM4CKDM5A | |
| SCHEMBL2828338 | 0.79 | SMN1; SMN2 (0.41) | ALDH1A1GAAMAPK1MAPTL3MBTL1 | |
| SCHEMBL1996275 | 0.78 | PDE4B (0.48) | ALDH1A1MAPK1KDM4CMAPTL3MBTL1 | |
| SCHEMBL2827049 | 0.77 | KMT2A (0.39) | ALDH1A1MAPTL3MBTL1KDM4EPOLB | |
| SCHEMBL2828825 | 0.76 | KMT2A (0.40) | ALDH1A1GAAMAPK1MAPTL3MBTL1 | |
| SCHEMBL2830985 | 0.76 | KMT2A (0.38) | ALDH1A1HTTTRPV1MAPTL3MBTL1 | |
| SCHEMBL2829802 | 0.75 | KMT2A (0.41) | ALDH1A1MAPK1MAPTL3MBTL1KDM4E | |
| SCHEMBL2828358 | 0.74 | MAPT (0.37) | ALDH1A1GAAMAPK1MAPTL3MBTL1 | |
| SCHEMBL2825496 | 0.74 | MAPT (0.38) | ALDH1A1MAPTL3MBTL1KDM4EPOLB | |
| SCHEMBL1997127 | 0.74 | GAA (0.39) | ALDH1A1HTTTRPV1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |