Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828825 | 0.91 | KMT2A (0.40) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2829802 | 0.89 | KMT2A (0.41) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2828358 | 0.89 | MAPT (0.37) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2825496 | 0.89 | MAPT (0.38) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2831318 | 0.88 | PKM (0.44) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2825646 | 0.87 | ALDH1A1 (0.40) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2828005 | 0.87 | PDE4B (0.41) | MAPTALDH1A1L3MBTL1KDM4EKMT2A | |
| SCHEMBL2828381 | 0.87 | KMT2A (0.37) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL2828384 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E | |
| SCHEMBL1996275 | 0.87 | PDE4B (0.48) | SMN1; SMN2MAPTALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |