Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 16/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | KDM6B | O15054 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826467 | 0.86 | ALDH1A1 (0.38) | KDM4CKDM5AKDM5BALDH1A1HTT | |
| SCHEMBL2829340 | 0.76 | KDM4C (0.41) | KDM4CKDM5AKDM6B | |
| SCHEMBL2828120 | 0.76 | KDM4C (0.38) | KDM4CALDH1A1KDM6B | |
| SCHEMBL1997947 | 0.75 | PDE4B (0.45) | KDM4CKDM6B | |
| SCHEMBL2825391 | 0.74 | KDM4C (0.40) | KDM4CKDM6B | |
| SCHEMBL2828862 | 0.74 | KDM4C (0.38) | KDM4C | |
| SCHEMBL1996126 | 0.73 | KDM4C (0.36) | KDM4CKDM5AKDM5BALDH1A1NR3C1 | |
| SCHEMBL2826007 | 0.72 | KDM4C (0.35) | KDM4C | |
| SCHEMBL2828388 | 0.72 | PDE4B (0.39) | KDM4CALDH1A1 | |
| SCHEMBL4054444 | 0.72 | PDE4B (0.56) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |