Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.44 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.44 |
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28265660 | 0.80 | IDO1 (0.46) | CLK4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL28267446 | 0.79 | CLK4 (0.40) | PNMTCLK4CDC7DAPK3MAP4K4 | |
| SCHEMBL28267174 | 0.77 | CDC7 (0.38) | CD274PDCD1LG2CLK4CDC7DAPK3 | |
| SCHEMBL28043877 | 0.76 | HSP90AA1 (0.59) | CD274PDCD1LG2PNMTCLK4CDC7 | |
| SCHEMBL16655898 | 0.76 | DPP4 (0.53) | PNMTCLK4CDC7DAPK3MAP4K4 | |
| SCHEMBL14050408 | 0.75 | CLK4 (0.46) | CLK4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL4436881 | 0.75 | CYP2D6 (0.47) | CLK4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL1415582 | 0.73 | CLK4 (0.45) | CLK4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL4429838 | 0.72 | CYP2D6 (0.44) | CLK4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL28151150 | 0.70 | IDO1 (0.49) | CLK4CDC7DAPK3MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |