Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | PRKX | P51817 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28265686 | 0.76 | CD274 (0.44) | DPP4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL439097 | 0.75 | DPP4 (0.63) | DPP4LOXL2CCR9PNMTS100A4 | |
| SCHEMBL30595830 | 0.73 | DPP4 (0.57) | DPP4CDK7CDK5DYRK1ALOXL2 | |
| SCHEMBL1275952 | 0.73 | DPP4 (0.57) | DPP4CDK7CDK5DYRK1ALOXL2 | |
| SCHEMBL28267174 | 0.70 | CDC7 (0.38) | DPP4CDC7DAPK3MAP4K4PIM1 | |
| SCHEMBL1265477 | 0.68 | CDC7 (0.56) | CDC7DAPK3MAP4K4PIM1PRKACA | |
| SCHEMBL904651 | 0.68 | — | — | |
| SCHEMBL16793938 | 0.68 | AAK1 (0.40) | CDC7DAPK3MAP4K4PIM1PRKACA | |
| SCHEMBL29676551 | 0.68 | AAK1 (0.40) | CDC7DAPK3MAP4K4PIM1PRKACA | |
| SCHEMBL29394904 | 0.67 | KDM4E (0.56) | CDC7DAPK3MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |