Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 9/20 | 0.53 |
| ▸ | TP53 | P04637 | 6/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877590 | 0.86 | L3MBTL1 (0.72) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL11529770 | 0.83 | MAPT (0.67) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL28868200 | 0.81 | MCL1 (0.65) | MAPTL3MBTL1MEN1KMT2AMCL1 | |
| SCHEMBL30547707 | 0.80 | KDM4E (0.68) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL5599830 | 0.80 | KDM4E (0.68) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL9613264 | 0.79 | THRB (0.61) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL12868305 | 0.76 | THRB (0.58) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL28264529 | 0.76 | MCL1 (0.61) | THRBMAPTL3MBTL1GFERMCL1 | |
| SCHEMBL7881270 | 0.73 | L3MBTL1 (0.59) | THRBMAPTL3MBTL1LMNATP53 | |
| SCHEMBL28264535 | 0.72 | MEN1 (0.50) | THRBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153643-A | Substituted indole MCL-1 inhibitors | 范德比尔特大学 | 2019-01-04 | — | — | CN | disclosed |