Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.64 |
| ▸ | TGM2 | P21980 | 1/20 | 0.60 |
| ▸ | HINT1 | P49773 | 3/20 | 0.57 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.56 |
| ▸ | KRAS | P01116 | 6/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410893 | 0.93 | TGM2 (0.61) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL17586739 | 0.93 | NT5E (0.69) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL2315499 | 0.93 | NT5E (0.69) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL14659955 | 0.92 | NT5E (0.63) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL2444656 | 0.91 | NT5E (0.62) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL94114 | 0.91 | NT5E (0.64) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL1533806 | 0.91 | NT5E (0.64) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL1971280 | 0.91 | NT5E (0.64) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL1971274 | 0.91 | NT5E (0.64) | NT5ETGM2HINT1FUT5KRAS | |
| SCHEMBL3294912 | 0.90 | NT5E (0.63) | NT5ETGM2HINT1FUT5KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2207891-A2 | MATERIALS AND METHODS FOR THE GENERATION OF TRANSCRIPTS COMPRISING MODIFIED NUCLEOTIDES | Archemix Corp. (US) | 2010-07-21 | — | — | EP | disclosed |
| WO-2008078180-A2 | MATERIALS AND METHODS FOR THE GENERATION OF TRANSCRIPTS COMPRISING MODIFIED NUCLEOTIDES | ARCHEMIX CORP. (US) | 2008-07-03 | — | — | WO | disclosed |