SCHEMBL94114

SCHEMBL94114

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](OP(=O)(O)O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.64
ADORA1 P30542 1/20 0.59
TGM2 P21980 1/20 0.59
HPGD P15428 2/20 0.56
HINT1 P49773 1/20 0.56
IMPDH2 P12268 5/20 0.56
IMPDH1 P20839 1/20 0.56
TAS1R3 Q7RTX0 2/20 0.56
TAS1R1 Q7RTX1 2/20 0.56
FUT5 Q11128 1/20 0.55
KRAS P01116 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1533806 1.00 NT5E (0.64) NT5EADORA1TGM2HPGDHINT1
SCHEMBL11327141 0.94 NT5E (0.63) NT5EADORA1TGM2HPGDHINT1
SCHEMBL29392340 0.93 TAS1R3 (0.58) NT5EADORA1TGM2HPGDHINT1
SCHEMBL1445061 0.93 TGM2 (0.60) NT5EADORA1TGM2HPGDHINT1
SCHEMBL1445069 0.93 TGM2 (0.60) NT5EADORA1TGM2HPGDHINT1
SCHEMBL17586739 0.93 NT5E (0.69) NT5ETGM2HINT1IMPDH2IMPDH1
SCHEMBL2315499 0.93 NT5E (0.69) NT5ETGM2HINT1IMPDH2IMPDH1
SCHEMBL1971274 0.93 NT5E (0.64) NT5EADORA1TGM2HINT1IMPDH2
SCHEMBL2220159 0.93 ADORA1 (0.67) NT5EADORA1TGM2HPGDHINT1
SCHEMBL1971280 0.93 NT5E (0.64) NT5EADORA1TGM2HINT1IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3816176-B1 HYDRATE CRYSTAL OF 3',3'-CGAMP YAMASA CORP (JP) 2026-03-04 EP claimed
US-20250333730-A1 SIRNA FOR INHIBITING ANGPTL3 GENE EXPRESSION AND USE THEREOF SHANGHAI JUNSHI BIOSCIENCES CO LTD (CN) 2025-10-30 US claimed
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE TEAM MEDICAL, LLC 2025-09-18 US claimed
US-20250250573-A1 POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF FXI, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF SIRIUS THERAPEUTICS, INC. 2025-08-07 US claimed
EP-4594484-A2 POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF FXI, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Sirius Therapeutics, Inc. (US) 2025-08-06 EP claimed
EP-4569114-A2 POLYNUCLEIC ACID MOLECULES TARGETING APOC3 AND USES THEREOF Sirius Therapeutics, Inc. (US) 2025-06-18 EP claimed
EP-4568682-A2 POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF LP(A), PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Sirius Therapeutics, Inc. (US) 2025-06-18 EP claimed
US-20250188464-A1 POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF LP(A), PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF SIRIUS THERAPEUTICS, INC. 2025-06-12 US claimed
US-20250188465-A1 POLYNUCLEIC ACID MOLECULES TARGETING APOC3 AND USES THEREOF SIRIUS THERAPEUTICS, INC. 2025-06-12 US claimed
CN-120077134-A APOC 3-targeted polynucleic acid molecule and application thereof 靖因药业有限公司 2025-05-30 CN claimed
EP-1501938-B1 ANALYSIS OF SUBSTRATE UTILIZATION BY ANIMAL OR PLANT CELLS BIOLOG INC (US) 2009-10-21 EP claimed
EP-1401500-A4 NUCLEOTIDE COMPOUNDS THAT BLOCK THE BITTER TASTE OF ORAL COMPOSITIONS LINGUAGEN CORP (US) 2006-06-14 EP claimed
US-6727076-B2 UTILIZES A GEL FORMING MATRIX FOR THE RAPID SCREENING OF CLINICAL AND ENVIRONMENTAL CULTURES BIOLOG, INC. 2004-04-27 US claimed
EP-1401500-A1 NUCLEOTIDE COMPOUNDS THAT BLOCK THE BITTER TASTE OF ORAL COMPOSITIONS Linguagen Corp. (US) 2004-03-31 EP claimed
WO-2004019885-A2 FAST DISSOLVING FILM DELIVERY OF NUCLEOTIDES THAT INHIBIT THE UNPLEASANT TASTE OF BITTER TASTING MEDICATIONS LINGUAGEN CORP. (US) 2004-03-11 WO claimed
US-20030162164-A1 Comparative phenotype analysis of cells, including testing of biologically active compounds BIOLOG, INC. 2003-08-28 US claimed
WO-2002096464-A1 NUCLEOTIDE COMPOUNDS THAT BLOCK THE BITTER TASTE OF ORAL COMPOSITIONS LINGUAGEN CORP. (US) 2002-12-05 WO claimed
US-20020177576-A1 Nucleotide compounds that block the bitter taste of oral compositions REDPOINT BIO CORPORATION 2002-11-28 US claimed
US-6472201-B1 GROWING AND TESTING MICROORGANISMS IN A MULTITEST FORMAT WHICH UTILIZES A GEL FORMING MATRIX FOR THE RAPID SCREENING OF CLINICAL AND ENVIRONMENTAL CULTURES BIOLOG, INC. 2002-10-29 US claimed
US-4577012-A ABSORPTION ON ACTIVATED CARBON, ELUTION WITH ALKALI HYDROXIDE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020177576-A1 Nucleotide compounds that block the bitter taste of oral compositions NUDT1, P2RY1, TAS2R40 NT5E 48/4885ADORA1 70/4885TGM2 3218/4885
US-20250333730-A1 SIRNA FOR INHIBITING ANGPTL3 GENE EXPRESSION AND USE THEREOF TEK, TIE1, PCSK9 NT5E 2645/4885ADORA1 4077/4885TGM2 2572/4885
US-20250188464-A1 POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF LP(A), PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF LPL, LDLR, PNLIP NT5E 101/4885ADORA1 1203/4885TGM2 3834/4885
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE SYNCRIP, SNRPA, RNASE1 NT5E 202/4885ADORA1 935/4885TGM2 3293/4885
US-20250250573-A1 POLYNUCLEIC ACID MOLECULES FOR INHIBITING EXPRESSION OF FXI, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF F13B, F13A1, F12 NT5E 113/4885ADORA1 2664/4885TGM2 3197/4885
US-20250188465-A1 POLYNUCLEIC ACID MOLECULES TARGETING APOC3 AND USES THEREOF APOB, APOL1, NOP10 NT5E 271/4885ADORA1 3557/4885TGM2 3250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.