SCHEMBL28266243

SCHEMBL28266243

COC(=O)c1ccc(Nc2ccc(Cl)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.58
KDR P35968 1/20 0.57
CDC25A P30304 1/20 0.56
CDC25B P30305 1/20 0.56
MEN1 O00255 5/20 0.55
KMT2A Q03164 5/20 0.55
KDM4E B2RXH2 2/20 0.54
HPGD P15428 2/20 0.54
RXFP1 Q9HBX9 1/20 0.54
MAPT P10636 5/20 0.54
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
CA1 P00915 2/20 0.53
CA2 P00918 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
CA12 O43570 1/20 0.53
CA7 P43166 1/20 0.53
CA9 Q16790 1/20 0.53
CA14 Q9ULX7 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL196916 0.90 CA1 (0.64) MEN1KMT2AKDM4EHPGDMAPT
SCHEMBL1505883 0.90 MEN1 (0.64) MEN1KMT2AKDM4EHPGDRXFP1
SCHEMBL4113542 0.85 MAPT (0.72) MEN1KMT2AKDM4EMAPTNPC1
SCHEMBL230366 0.84 MAPT (0.51) DHODHKDRCDC25ACDC25BMEN1
SCHEMBL3297101 0.84 HPGD (0.66) HPGDMAPTNPC1RAB9ACA1
SCHEMBL14926631 0.84 CA1 (0.58) DHODHKDRMAPTNPC1RAB9A
SCHEMBL21242859 0.84 NPC1 (0.71) MEN1KMT2AKDM4EHPGDMAPT
SCHEMBL5928751 0.83 RAB9A (0.74) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL14563274 0.83 TRPV1 (0.56) CDC25ACDC25BMEN1KMT2AKDM4E
SCHEMBL71303 0.82 TSHR (0.69) CDC25ACDC25BMEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109206360-A Carbazole amide derivatives or its salt and its preparation method and application 复旦大学 2019-01-15 CN disclosed