Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28267598 | 0.87 | TLR8 (0.55) | TLR8HRH4 | |
| SCHEMBL28265781 | 0.86 | ALDH1A1 (0.46) | TLR8HRH4MAPK8 | |
| SCHEMBL28265742 | 0.85 | TLR8 (0.46) | TLR8HRH4 | |
| SCHEMBL28267608 | 0.85 | TLR8 (0.50) | TLR8HRH4NPY5R | |
| SCHEMBL28265753 | 0.84 | TLR8 (0.46) | TLR8HRH4 | |
| SCHEMBL15758068 | 0.83 | NUDT1 (0.51) | TLR8HRH4TDP1NPY5RAGTR1 | |
| SCHEMBL28265690 | 0.81 | MAPT (0.45) | TLR8HRH4MAPK8TP53 | |
| SCHEMBL28265699 | 0.80 | MAPK14 (0.46) | TLR8HRH4MAPK8 | |
| SCHEMBL28265859 | 0.80 | TLR8 (0.43) | TLR8HRH4TDP1 | |
| SCHEMBL28267602 | 0.79 | HRH4 (0.47) | TLR8HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |