SCHEMBL28268751

SCHEMBL28268751

COC(=O)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.74

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.74
NPC1 O15118 7/20 0.66
MEN1 O00255 5/20 0.66
KMT2A Q03164 5/20 0.66
MAPT P10636 4/20 0.66
LMNA P02545 1/20 0.66
PTGS1 P23219 1/20 0.64
SMN1; SMN2 Q16637 3/20 0.63
TP53 P04637 1/20 0.63
KCNK3 O14649 2/20 0.60
GPR17 Q13304 1/20 0.59
CES1 P23141 1/20 0.58
HTT P42858 2/20 0.58
NPSR1 Q6W5P4 1/20 0.57
ABL1 P00519 1/20 0.57
RIN1 Q13671 1/20 0.57
KCNK9 Q9NPC2 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5350952 0.90 MAPT (0.72) RAB9AMEN1KMT2AMAPTLMNA
SCHEMBL28007803 0.87 RAB9A (0.70) RAB9ANPC1MEN1KMT2AMAPT
SCHEMBL1815533 0.86 RAB9A (0.78) RAB9ANPC1MEN1KMT2AMAPT
SCHEMBL677770 0.85 RAB9A (1.00) RAB9ANPC1MEN1KMT2AMAPT
SCHEMBL7519747 0.85 MAPT (0.82) RAB9ANPC1MEN1KMT2AMAPT
SCHEMBL13709105 0.85 RAB9A (0.60) RAB9AMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL13465103 0.84 AKR1C3 (0.56) RAB9ANPC1MEN1KMT2AMAPT
SCHEMBL23070449 0.84 NR1H4 (0.72) RAB9ANPC1MEN1KMT2AMAPT
SCHEMBL6242208 0.84 RAB9A (0.84) RAB9ANPC1MEN1KMT2AMAPT
Hydrochloric Acid SCHEMBL2104426 0.83 NR1H4 (0.70) RAB9ANPC1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109096177-A 3- amido benzoic acid derivative, preparation method and medical usage 中国药科大学 2018-12-28 CN disclosed