Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829460 | 0.82 | GRM5 (0.53) | GRM5PORCN | |
| SCHEMBL2827141 | 0.78 | GRM5 (0.47) | GRM5MAPK1PORCNSMARCA2SMARCA4 | |
| SCHEMBL2833093 | 0.77 | GRM5 (0.69) | GRM5PORCNSMARCA2SMARCA4SORT1 | |
| SCHEMBL2830138 | 0.76 | GRM5 (0.49) | GRM5PORCNSMARCA2SMARCA4IKBKE | |
| SCHEMBL2833088 | 0.76 | GRM5 (0.56) | GRM5MAPK1PORCNSMARCA2SMARCA4 | |
| SCHEMBL2826714 | 0.76 | GRM5 (0.70) | GRM5PORCNSMARCA2SMARCA4 | |
| SCHEMBL2828525 | 0.75 | GRM5 (0.47) | GRM5PORCNSMARCA2SMARCA4SORT1 | |
| SCHEMBL2826446 | 0.75 | GRM5 (0.46) | GRM5MAPK1PORCNSMARCA2SMARCA4 | |
| SCHEMBL2830413 | 0.75 | GRM5 (0.51) | GRM5PORCNSMARCA2SMARCA4GSK3B | |
| SCHEMBL2832198 | 0.75 | GRM5 (0.52) | GRM5PORCNSMARCA2SMARCA4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |