Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.53 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826714 | 0.85 | GRM5 (0.70) | GRM5PORCNMAPT | |
| SCHEMBL2828498 | 0.83 | GRM5 (0.44) | GRM5KMT2AALDH1A1HTT | |
| SCHEMBL2826997 | 0.82 | GRM5 (0.44) | GRM5PORCN | |
| SCHEMBL2827141 | 0.80 | GRM5 (0.47) | GRM5PORCNSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2832198 | 0.80 | GRM5 (0.52) | GRM5PORCNMEN1KMT2A | |
| SCHEMBL2833093 | 0.79 | GRM5 (0.69) | GRM5PORCNMEN1KMT2A | |
| SCHEMBL2826783 | 0.79 | GRM5 (0.49) | GRM5PORCNMAPTCDK2ALDH1A1 | |
| SCHEMBL2830413 | 0.78 | GRM5 (0.51) | GRM5PORCNMAPT | |
| SCHEMBL2829074 | 0.78 | GRM5 (0.47) | GRM5PORCN | |
| SCHEMBL2829461 | 0.77 | GRM5 (0.48) | GRM5PORCNMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |