Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 10/20 | 0.35 |
| ▸ | JAK2 | O60674 | 9/20 | 0.35 |
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 6/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829035 | 0.85 | AURKB (0.37) | GRM5JAK1JAK2JAK3PTK2 | |
| SCHEMBL2833093 | 0.84 | GRM5 (0.69) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2826446 | 0.83 | GRM5 (0.46) | GRM5SMARCA2SMARCA4PORCNIKBKE | |
| SCHEMBL2829934 | 0.83 | GRM5 (0.52) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2826248 | 0.83 | SMARCA2 (0.56) | GRM5SMARCA2SMARCA4PORCNJAK1 | |
| SCHEMBL2833088 | 0.82 | GRM5 (0.56) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2826714 | 0.82 | GRM5 (0.70) | GRM5SMARCA2SMARCA4PORCNJAK2 | |
| SCHEMBL2826716 | 0.82 | GRM5 (0.50) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2826318 | 0.81 | GRM5 (0.54) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2831334 | 0.81 | GRM5 (0.54) | GRM5SMARCA2SMARCA4PORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |