Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1304619 | 0.80 | OPRM1 (0.60) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL12618031 | 0.75 | OPRM1 (0.51) | OPRM1OPRL1OPRK1OGFRL1 | |
| Citric Acid SCHEMBL1305034 | 0.72 | OPRM1 (0.48) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL14601364 | 0.71 | OPRM1 (0.76) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL3216799 | 0.64 | OPRM1 (0.47) | OPRM1OPRL1OPRK1OGFRL1DRD2 | |
| SCHEMBL2464748 | 0.63 | OPRM1 (0.64) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL208815 | 0.63 | OPRM1 (0.58) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL5569970 | 0.62 | OPRM1 (0.62) | OPRM1OPRL1OPRK1OGFRL1 | |
| Hydrochloric Acid SCHEMBL11729597 | 0.62 | OPRL1 (0.62) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL3214484 | 0.62 | OPRM1 (0.47) | OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116544-A2 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2009-11-11 | — | — | EP | claimed |
| EP-1560835-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | claimed |
| EP-2062898-A2 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2009-05-27 | — | — | EP | claimed |
| US-20060004034-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2006-01-05 | — | — | US | claimed |
| EP-2116544-B1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2016-05-18 | — | — | EP | disclosed |
| EP-2233487-B1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2016-05-18 | — | — | EP | disclosed |
| EP-2062898-B1 | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2013-10-02 | — | — | EP | disclosed |
| EP-2233487-A1 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |
| EP-2116544-A2 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2009-11-11 | — | — | EP | disclosed |
| EP-1560835-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | disclosed |
| US-7547707-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2009-06-16 | — | — | US | disclosed |
| EP-2062898-A2 | Spirocyclic cyclohexane derivatives | Grünenthal GmbH (DE) | 2009-05-27 | — | — | EP | disclosed |
| US-20060004034-A1 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004034-A1 | Spirocyclic cyclohexane compounds | PKD1, PKD2, HSD17B7 | OPRM1 1225/4885OPRL1 470/4885OPRK1 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.