Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.62 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827026 | 0.92 | HSD11B1 (0.70) | HSD11B1HSD11B2DPP4GAAKDM4E | |
| SCHEMBL2827028 | 0.92 | HSD11B1 (0.70) | HSD11B1HSD11B2DPP4GAAKDM4E | |
| SCHEMBL2828305 | 0.77 | HSD11B1 (0.57) | HSD11B1HSD11B2MAPTALDH1A1 | |
| SCHEMBL2828307 | 0.77 | HSD11B1 (0.57) | HSD11B1HSD11B2MAPTALDH1A1 | |
| SCHEMBL2827241 | 0.76 | HSD11B1 (0.57) | HSD11B1HSD11B2MAPTALDH1A1 | |
| SCHEMBL2824524 | 0.75 | HSD11B1 (0.56) | HSD11B1HSD11B2MAPTALDH1A1 | |
| SCHEMBL2830783 | 0.74 | HSD11B1 (0.77) | HSD11B1HSD11B2 | |
| SCHEMBL2830784 | 0.74 | HSD11B1 (0.77) | HSD11B1HSD11B2 | |
| SCHEMBL2827031 | 0.74 | HSD11B1 (0.57) | HSD11B1HSD11B2DPP4GAAKDM4E | |
| SCHEMBL2826450 | 0.73 | HSD11B1 (0.62) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |