Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421404 | 0.89 | MC4R (0.39) | MC4RCHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL997411 | 0.82 | MEN1 (0.34) | CHRM2CHRM5CYP2D6CHRM1CHRM3 | |
| SCHEMBL10522315 | 0.82 | MEN1 (0.34) | CHRM2CHRM5CYP2D6CHRM1CHRM3 | |
| SCHEMBL6367938 | 0.79 | — | — | |
| SCHEMBL9127282 | 0.76 | MC4R (0.32) | MC4R | |
| SCHEMBL4934569 | 0.75 | OPRM1 (0.33) | CHRM5CHRM3OPRM1 | |
| Piperazine SCHEMBL28181609 | 0.74 | HIF1A (0.46) | HTR2AHTR2CPHGDH | |
| SCHEMBL17664786 | 0.72 | MC4R (0.34) | MC4RCHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL7050375 | 0.71 | MC4R (0.31) | MC4R | |
| SCHEMBL16289999 | 0.69 | PHGDH (0.43) | HTR2AHTR2CPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109321087-A | A kind of thick coated type steel structure surface high flexibility epoxy coating | 厦门柏润氟材料科技有限公司 | 2019-02-12 | — | — | CN | claimed |