Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL28085448 | 0.88 | TP53 (0.40) | TP53 | |
| Diethylamine SCHEMBL17220640 | 0.83 | TP53 (0.44) | PLA2G1BPLA2G2ATP53 | |
| Diethylamine SCHEMBL28081053 | 0.82 | — | — | |
| Diethylamine SCHEMBL28829636 | 0.79 | TP53 (0.36) | PLA2G1BPLA2G2ATP53 | |
| Trimethylammonium SCHEMBL28069178 | 0.76 | KCNH2 (0.34) | PLA2G1BPLA2G2A | |
| Isopropylamine SCHEMBL177414 | 0.76 | PLA2G1B (0.36) | PLA2G1BPLA2G2A | |
| Diethylamine SCHEMBL28268698 | 0.76 | TP53 (0.53) | TP53 | |
| Diethylamine SCHEMBL7543246 | 0.71 | — | — | |
| SCHEMBL808836 | 0.71 | KCNH2 (0.37) | PLA2G1BPLA2G2A | |
| Diethylamine SCHEMBL1806685 | 0.71 | TP53 (0.61) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109310713-A | Methods for controlled proliferation/generation of inner ear hair cells from vestibular stem cells using WNT and TGF-beta inhibition | 频率治疗公司 | 2019-02-05 | — | — | CN | disclosed |