Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28280227 | 0.85 | GRM5 (0.42) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL29590211 | 0.84 | RAB9A (0.62) | NPC1NAMPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL29589890 | 0.82 | NAMPT (0.59) | NPC1NAMPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL23327029 | 0.79 | NPC1 (0.68) | NPC1POLBRAB9ASMN1; SMN2TP53 | |
| SCHEMBL23327023 | 0.79 | NPC1 (0.55) | NPC1POLBNAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL29591192 | 0.75 | BCL2 (0.51) | NPC1POLBNAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL29587968 | 0.73 | NAMPT (0.57) | NAMPTBCL2 | |
| SCHEMBL29590466 | 0.72 | HSP90AA1 (0.47) | NPC1NAMPTSMN1; SMN2TP53KMT2A | |
| SCHEMBL29590775 | 0.72 | HSP90AA1 (0.47) | NPC1NAMPTSMN1; SMN2TP53KMT2A | |
| SCHEMBL16416972 | 0.72 | HSP90AA1 (0.47) | NPC1NAMPTSMN1; SMN2TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456324-A | New isoindoline or isoquinoline compound, preparation method and the Pharmaceutical composition containing them | 法国施维雅药厂 | 2019-03-12 | — | — | CN | disclosed |