Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827578 | 0.88 | GRM5 (0.50) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2829012 | 0.85 | GRM5 (0.41) | GRM5MAPTKDM4ENPC1RAB9A | |
| SCHEMBL15663639 | 0.84 | GRM5 (0.44) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2829127 | 0.84 | GRM5 (0.46) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2832741 | 0.83 | GRM5 (0.44) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2828125 | 0.82 | GRM5 (0.50) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2827389 | 0.81 | GRM5 (0.51) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2827009 | 0.78 | GRM5 (0.53) | GRM5MAPTSMN1; SMN2HPGDMAPK1 | |
| SCHEMBL2825827 | 0.78 | GRM5 (0.47) | GRM5MAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2824785 | 0.77 | GRM5 (0.70) | GRM5MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |