Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829064 | 0.89 | GRM5 (0.41) | GRM5NPC1MAPTRAB9AKDM4E | |
| SCHEMBL2827912 | 0.85 | GRM5 (0.44) | GRM5NPC1MAPTRAB9AKDM4E | |
| SCHEMBL2828250 | 0.84 | ADORA1 (0.41) | GRM5NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL2830056 | 0.82 | GRM5 (0.39) | GRM5NPC1RAB9A | |
| SCHEMBL2829129 | 0.79 | GRM5 (0.41) | GRM5LMNANPC1MAPTRAB9A | |
| SCHEMBL2829032 | 0.78 | NPC1 (0.41) | GRM5NPC1MAPTRAB9AKDM4E | |
| SCHEMBL2832204 | 0.77 | GRM5 (0.56) | GRM5 | |
| SCHEMBL2826802 | 0.77 | RAB9A (0.43) | GRM5LMNANPC1MAPTRAB9A | |
| SCHEMBL2831334 | 0.77 | GRM5 (0.54) | GRM5NPC1RAB9A | |
| SCHEMBL2829033 | 0.76 | GRM5 (0.44) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |