Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826781 | 0.90 | GRM5 (0.52) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL2826714 | 0.88 | GRM5 (0.70) | GRM5MAPTJAK2JAK3ABL1 | |
| SCHEMBL2824577 | 0.87 | GRM5 (0.49) | GRM5SMN1; SMN2NPC1RAB9AJAK2 | |
| SCHEMBL2827196 | 0.87 | GRM5 (0.58) | GRM5LMNANPC1JAK2JAK3 | |
| SCHEMBL2826392 | 0.86 | GRM5 (0.48) | GRM5SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL2824785 | 0.84 | GRM5 (0.70) | GRM5NPC1RAB9AJAK2JAK3 | |
| SCHEMBL2831112 | 0.84 | IRAK4 (0.46) | GRM5SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL2826008 | 0.84 | GRM5 (0.57) | GRM5SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL2826273 | 0.83 | GRM5 (0.56) | GRM5SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL2830196 | 0.82 | GRM5 (0.47) | GRM5SMN1; SMN2GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |