Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC13A5 | Q86YT5 | 12/20 | 0.39 |
| ▸ | SLC13A2 | Q13183 | 1/20 | 0.39 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28467031 | 1.00 | ALDH1A1 (0.48) | ALDH1A1SLC13A5SLC13A2SLC13A3KDM4E | |
| Glycolic Acid SCHEMBL28396238 | 0.83 | NOTUM (0.33) | — | |
| Glycolic Acid SCHEMBL19615736 | 0.83 | NOTUM (0.33) | — | |
| Succinic Acid SCHEMBL22691726 | 0.79 | NPSR1 (0.39) | KDM4ELMNAMEN1KMT2A | |
| Succinic Acid SCHEMBL21679544 | 0.73 | NPSR1 (0.35) | LMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9361094 | 0.72 | ALDH1A1 (0.94) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL28724140 | 0.72 | ALDH1A1 (0.94) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL432573 | 0.72 | ALDH1A1 (0.94) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL29486777 | 0.72 | ALDH1A1 (0.94) | ALDH1A1SLC13A5KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL1854661 | 0.72 | ALDH1A1 (0.94) | ALDH1A1SLC13A5KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981230-A | Mixture comprising a solid support containing a urease inhibitor and a further solid support containing a nitrification inhibitor | 巴斯夫欧洲公司 | 2022-08-30 | — | — | CN | claimed |
| CN-114980741-A | Mixture comprising nitrification inhibitor and carrier | 巴斯夫欧洲公司 | 2022-08-30 | — | — | CN | claimed |
| CN-111010874-A | Mixtures comprising at least two different nitrification inhibitors selected from 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA), 3, 4-dimethylpyrazolium glycolate (DMPG) and other compounds, in particular mixtures comprising DMPSA and DMP/DMPP or mixtures comprising DMPSA and DCD | 巴斯夫欧洲公司 | 2020-04-14 | — | — | CN | claimed |
| CN-110914223-A | Mixture comprising a biopesticide and a nitrification inhibitor | 巴斯夫欧洲公司 | 2020-03-24 | — | — | CN | claimed |
| CN-110914222-A | Mixtures comprising herbicides and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) | 巴斯夫欧洲公司 | 2020-03-24 | — | — | CN | claimed |
| CN-110891923-A | Mixtures comprising Urease Inhibitors (UI) and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) | 巴斯夫欧洲公司 | 2020-03-17 | — | — | CN | claimed |
| CN-110869336-A | Mixtures comprising fungicides and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) | 巴斯夫欧洲公司 | 2020-03-06 | — | — | CN | claimed |
| CN-116437806-A | Fertilizer compatible agrochemical suspensions | 巴斯夫欧洲公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-116157017-A | 3- (pyridazin-4-yl) -5, 6-dihydro-4H-1, 2, 4-oxadiazine derivatives as fungicides for crop protection | 拜耳公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-115915941-A | Pyridine (thio) amides as fungicidal compounds | 拜耳公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-114981230-A | Mixture comprising a solid support containing a urease inhibitor and a further solid support containing a nitrification inhibitor | 巴斯夫欧洲公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-114980741-A | Mixture comprising nitrification inhibitor and carrier | 巴斯夫欧洲公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-111010874-A | Mixtures comprising at least two different nitrification inhibitors selected from 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA), 3, 4-dimethylpyrazolium glycolate (DMPG) and other compounds, in particular mixtures comprising DMPSA and DMP/DMPP or mixtures comprising DMPSA and DCD | 巴斯夫欧洲公司 | 2020-04-14 | — | — | CN | disclosed |
| CN-110914223-A | Mixture comprising a biopesticide and a nitrification inhibitor | 巴斯夫欧洲公司 | 2020-03-24 | — | — | CN | disclosed |
| CN-110914222-A | Mixtures comprising herbicides and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) | 巴斯夫欧洲公司 | 2020-03-24 | — | — | CN | disclosed |
| CN-110891923-A | Mixtures comprising Urease Inhibitors (UI) and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) | 巴斯夫欧洲公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-110869336-A | Mixtures comprising fungicides and nitrification inhibitors, such as 2- (3, 4-dimethyl-1H-pyrazol-1-yl) succinic acid (DMPSA) or 3, 4-dimethylpyrazolium glycolate (DMPG) | 巴斯夫欧洲公司 | 2020-03-06 | — | — | CN | disclosed |
| CN-109476561-A | Capsule comprising being used as the benzyl propargyl ether of nitrification inhibitor | 巴斯夫欧洲公司 | 2019-03-15 | — | — | CN | disclosed |